Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Novel insights on the biology and immunologic effects of histamine: A road map for allergists and mast cell biologists Journal of Allergy and Clinical Immunology Understanding MCAS and Hypermobility: Overlapping Conditions Mast Cell Activation Syndrome (MCAS): A Functional Approach to Histamine Intolerance
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