A Review of The Contribution of Gut Dependent Microbiota Derived Marker, Trimethylamine N oxide (TMAO), in Coronary Artery Disease Current Research in Nutrition and Food Science Journal Trimethylamine N oxide (TMAO) is a small molecule produced in humans primarily by the gut liver axis and has become an important biomarker, and possible mediator, of cardiometabolic and renal disease. Dietary choline, phosphatidylcholine ( TMAO: The Gut Metabolite Linking Red Meat to Cardiovascular Disease The Intricate Gut Heart Connection; The Role of Gut Microbiota in the Pathogenesis of Cardiovascular Disease