Alliwise Liposomal Glutathione Supplement, Max Absorption, Powerful Antioxidant, 120 Softgels : Target Liposomal Glutathione Supplement 60 Vegetable Capsules Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Deficient Glutathione in the Pathophysiology of Mycotoxin Related Illness