Glutathione and Autoimmune Disease Master Antioxidant Alcohol metabolism and why a few drinks linger longer than you think Your body processes >90% of ethanol in the liver, but the path creates toxic byproducts and drains key cofactors. 1 JCI Hepatic glutathione depletion ameliorates MASLD through selective protein oxidation and inhibition of lipogenesis Chronic Glutathione Depletion Confers Protection against Alcohol induced Steatosis: Implication for Redox Activation of AMP activated Protein Kinase Pathway Scientific Reports